Primary Adrenal Insufficiency due to Cryptococcus with Persistent Adrenal Enlargement and Insufficiency

نویسندگان

چکیده

Background/ObjectiveInfiltrative fungal infections are an unusual cause of primary adrenal insufficiency (AI). Our objective is to present long term follow-up a patient with AI due crytpococcal adrenalitis.Case ReportA 47 year old woman presented in January 2004 50 lb. weight loss, nausea, emesis, and headache diplopia. During the 6 months prior her presentation had multiple admissions for evaluation recurrent nausea emesis. Prior most recent these developed headache; cerebrospinal fluid revealed cryptococcus she was treated two week course Amphotericin B. Physical examination demonstrated temperature 101.1 °F, HR 110 bpm, BP 94/65 mmHg, ill appearing underweight dry mucous membranes, photophobia. Laboratory random cortisol 0.5 ug/dL. CT imaging showed bilateral gland enlargement FNA encapsulated budding yeast. Stress dose IV glucocorticoids were administered switched oral Hydrocortisone Fludrocortisone as clinically improved second Further 2017 persistently enlarged glands, positive antigen low IgG levels.DiscussionOur literature review noted few publications caused by disseminated no follow up cases beyond 1-4 time frame.ConclusionPatients infect warrant assess resolution immunocompromised status.

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ژورنال

عنوان ژورنال: AACE clinical case reports

سال: 2023

ISSN: ['2376-0605']

DOI: https://doi.org/10.1016/j.aace.2023.09.002